科马亚瓜（Comayagua）是洪都拉斯的一座城市，为科马亚瓜省省会。

2008年科马亚瓜有87,805名居民。

科马亚瓜位于特古西加尔巴西北80公里，圣佩德罗苏拉南约77.6英里。

Comayagua (Spanish pronunciation: [komaˈʝaɣwa]) is a city in Honduras, some 50 miles (80 km) northwest of Tegucigalpa on the highway to San Pedro Sula at an elevation of 1,949 feet (594 m) above sea level.

In 2015 the estimated population was 152,051 people. It is the capital of the Comayagua department of Honduras. The city is noted for its wealth of Spanish Colonial architecture. The central square has a cathedral with the oldest clock in the Americas.