Clorgiline

Clorgiline (INN), or clorgyline (BAN), is a monoamine oxidase inhibitor (MAOI) structurally related to pargyline which is described as an antidepressant. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research. In addition to its actions as an MAOI, clorgiline has been found to bind with high affinity to the σ₁ receptor (K_i = 3.2 nM) and with very high affinity to the I₂ imidazoline receptor (an allosteric site on the monoamine oxidase enzyme) (K_i = 40 pM).

单词	Clorgyline
释义	Clorgyline 英语百科 Clorgiline Clorgiline (INN), or clorgyline (BAN), is a monoamine oxidase inhibitor (MAOI) structurally related to pargyline which is described as an antidepressant. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research. In addition to its actions as an MAOI, clorgiline has been found to bind with high affinity to the σ₁ receptor (K_i = 3.2 nM) and with very high affinity to the I₂ imidazoline receptor (an allosteric site on the monoamine oxidase enzyme) (K_i = 40 pM).
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Clorgyline

Clorgiline