氯苯那敏（Chlorpheniramine），又称扑尔敏，是用在预防过敏性疾病如鼻炎和荨麻疹症状中使用的第一代烷基胺抗组胺药。相比于其他第一代抗组胺药其镇静作用较弱。氯苯那敏是在兽医，小动物中最常用的抗组胺剂之一。虽然通常不作为抗抑郁药或抗焦虑药，氯苯那敏似乎具有这些特性，是一种用于过敏症状的药物，属于第一代组胺H1受体拮抗剂（又称抗组织胺药），化学式C₁₆H₁₉N₂Cl。生产药品时，通常使用其盐类马来酸氯苯那敏（Chlorpheniramine maleate）。

Chlorphenamine (INN), chlorpheniramine (USAN, former BAN) or piriton (trade name), commonly marketed in the form of chlorphenamine maleate (Chlorphen-12), is a first-generation alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorphenamine is one of the most commonly used antihistamines in small-animal veterinary practice. Although not generally approved as an antidepressant or anti-anxiety medication, chlorphenamine appears to have these properties as well.