These proliferating centroblasts form a germinal center, located in the center of the follicle of the lymph node.

这些不断增殖的中心母细胞形成生发中心，位于淋巴结滤泡的中心。

Other activated B-cells go to the center of a primary follicle in the lymph node and they differentiate into B-cells called centroblasts and start to proliferate or divide.

其它活化的B细胞进入淋巴结的初级滤泡中心，然后分化成中心母细胞，并开始增殖或分裂。

These centroblasts have a rearrangement of their immunoglobulin genes, and some of them undergo a class switch where they change from producing IgM antibodies to producing IgG or IgA antibodies.

这部分中心母细胞的免疫球蛋白基因发生了重排，其中的一些会经历Ig类别转换，从产生IgM变成产生IgG或IgA。