Castel di Lucio (Sicilian: Castiddruzzu) is a comune (municipality) in the Province of Messina in the Italian region Sicily, located about 90 kilometres (56 mi) southeast of Palermo and about 110 kilometres (68 mi) southwest of Messina. As of 31 December 2004, it had a population of 1,477 and an area of 28.4 square kilometres (11.0 sq mi).