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单词 Cartazolate
释义

Cartazolate

英语百科

Cartazolate

Cartazolate and Etazolate synthesis: HOEHN H, DENZEL T; DE 2123318  (1970 to E. R. Squibb & Sons Inc.).

Cartazolate (SQ-65,396) is a drug of the pyrazolopyridine class. It acts as a GABAA receptor positive allosteric modulator at the barbiturate binding site of the complex and has anxiolytic effects in animals. It is also known to act as an adenosine antagonist at the A1 and A2 subtypes and as a phosphodiesterase inhibitor. Cartazolate was tested in human clinical trials and was found to be efficacious for anxiety but was never marketed. It was developed by a team at E.R. Squibb and Sons in the 1970s.

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更新时间:2025/6/21 15:49:30