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单词 CAMKII
释义

CAMKII

中文百科

钙离子/钙调素依赖性蛋白激酶

(重定向自CaMKII)
钙调蛋白激酶
Une vue de l'holoenzyme gamma de la CaMKII dans la conformation ouverte (A) et fermée (B), par PDB 2ux0 et PDB 2v70
La structure du domaine de la CAMKII gamma, vue par pymol d'après PDB 2ux0 (à gauche) vue compacte (center) holoenzyme vue en feuillets bêta et hélices alpha (right) un monomère
La structure du domaine kinase de la CaMKII, vue par pymol d'après PDB 2v70, les bâtons verts correspondent à des nucléotides

钙离子/钙调素依赖的蛋白激酶钙调蛋白激酶(英文:Ca/calmo****n-dependent protein kinases or CaM kinases )是一种丝氨酸/苏氨酸特性的蛋白激酶,被钙/钙调蛋白复合物所调节。这个种系的蛋白在活化时表现出一种记忆效应。

英语百科

Ca2+/calmodulin-dependent protein kinase

CaMKII gamma holoenzyme in its (A) closed and the (B) open conformations
The structure of the association domain of CaMKII gamma rendered by pymol from PDB 2ux0 (left) space fill holoenzyme (center) cartoon holoemzyme (right) cartoon monome
The structure of the kinase domain of CaMKII rendered by pymol from PDB 2v70, green sticks = nucleotide

Ca2+/calmodulin-dependent protein kinase II (CaM kinase II or CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation.

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更新时间:2025/6/17 12:33:27