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单词 calcineurin
释义

calcineurin

英汉-汉英词典
钙依赖磷酸酶
词组 | 习惯用语
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  • neurological adj. 神经病学的
  • calcimine n. 墙粉(一种涂料) vt. 刷墙粉于
  • calcine vt. 烧成石灰;锻烧 vi. 煅烧
  • coalescence n. 合并,接合,联合
calcineurin n. 钙调磷酸酶
calcineurin inhibitors 钙调神经磷酸酶抑制剂(calcineurin inhibitor的复数)
calcineurin inhibitor 神经钙调蛋白抑制剂

网络短语:
calcineurin b 钙调磷酸酶b; 亚基基因;
calcineurin A 钙调磷酸酶基因; 该序列与钙依赖磷酸酶催化亚基;
calcineurin inhibitor CNI 抑制剂
calcineurin b-like proteins 钙调磷酸酶b类蛋白;亚基蛋白;类蛋白;蛋白
calcineurin b subunit 钙调神经磷酸酶b亚基
calcineurin signaling pathway 钙调神经磷酸酶信号通路
calcineurin a polyclonal antibody 钙调磷酸酶多克隆抗体
calcineurin b homologous protein 的结合蛋白;蛋白;钙调磷酸酶b同源蛋白
Recombinant human calcineurin B subunit 重组人钙调磷酸酶B亚基
中文百科

钙调磷酸酶

钙调磷酸酶英语:Calcineurin,亦称为蛋白磷酸酶3或蛋白磷酸酶2B,分别简称为PPP3CAPP2B)其在体内的作用为启动T细胞并可以通过药物来阻断这一过程。

钙调磷酸酶为很多种免疫抑制药的作用对象如,环孢霉素,吡美莫司和他克莫司。

英语百科

Calcineurin 钙调磷酸酶

Crystallographic structure of calcineurin heterodimer composed of the catalytic (PPP3CA) and regulatory (PPP3R1) subunits.[1]

Calcineurin (CaN) is a calcium and **** dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell, cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporin, pimecrolimus and tacrolimus.

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更新时间:2025/6/17 15:50:59