The expanded CAG repeats also affect DNA replication itself.

扩展的CAG重复序列也会影响DNA复制本身。

The expanded CAG repeats not only affect the huntingtin protein - they affect DNA replication itself.

多余的CAG序列不仅影响huntingtin蛋白，也影响了DNA本身的复制。

The average is around 40 years old, although remember the age of onset depends on the number of CAG repeats.

发病年龄平均为40岁左右，不过要记住，发病年龄取决于CAG序列重复的数量。

When copying the mutated gene, DNA polymerase can basically lose track of which CAG it's on and accidentally add extra CAGs.

在复制突变基因时，DNA聚合酶基本上无法定位它所处的CAG位置，并由此意外添加了额外的CAG。

When copying the HTT gene, DNA polymerase can basically lose track of which CAG it's on and accidently add extra CAGs.

当HTT基因复制时，DNA聚合酶基本上无法识别校对CAG序列，意外地导致CAG序列重复。

This expansion of the originally inherited gene means a child of a parent with HD can inherit even more CAG repeats than the parent did.

这种先天性的基因遗传导致的异常，意味着HD患者后代遗传得到的CAG重复序列比父母多。

This expansion of the originally inherited gene means a child of a parent with a disease can inherit even more CAG repeats than the parent.

原始遗传基因的扩展，意味着患病父母的孩子，与父/母相比，可能拥有更多的CAG重复。

CAG codes for the amino acid glutamine, so people with Huntington disease patients will have 36 or more glutamines in a row in the huntingtin protein.

因为CAG序列对应的是谷氨酰胺（氨基酸），所以在HD患者体内，huntingtin蛋白质上会有36个以上连续的谷氨酰胺。

Because of this penetrance, the test for HD, which counts the number of CAG repeats, is really good at determining whether HD will develop in an at-risk individual.

基于HD的外显性，HD测试，即检测CAG重复序列的数量，十分有助于确定高危人群是否会发展为HD。

Even repeats of 27-35 CAGs can expand occasionally; these are called " pre-mutation" alleles, since they don't cause the disease, but they're set-up for developing a mutation of 36 or more CAGs.

即使CAG序列重复在27-35次间，偶尔也会产生异常，这些被称为突变前等位基因，尽管不会引起疾病，但仍可能会发展为36次以上CAG序列重复的突变。