By the close of trading last week, the Standard and Poor's 500 was down more than 6 percent this year.

截至上周末收盘，标准普尔500指数今年已经下跌了超过6%。

Thus, by the close of the 19th century English rule had extended to the six principal continents (including British Guyana in South America).

大约在19世纪末时，英国的势力遍及全球主要的6大洲（包括位于南美洲的英属圭亚那）。

All things considered though, Africa certainly has the potential if it united to become a superpower by the close of the 21st century.

尽管有诸多不利因素，非洲确实潜力巨大，前提是它可以在21世纪结束以前成为统一的强国。

It was like $50.05 on September 8th, and then it drops down to $37.57 by the close of business on the 10th.

9 月 8 日大约是 50. 05 美元，然后在 10 日收盘时跌至 37. 57 美元。

By the close of the seventeenth century, New England manufactured cloth in sufficient quantities to export it to the Southern colonies and to the West Indies.

到 17 世纪末，新英格兰生产的布料数量足以出口到南部殖民地和西印度群岛。

As soon as a firm foothold was secured on the shore line they pressed westward until, by the close of the colonial period, they were already on the crest of the Alleghanies.

一旦在海岸线上站稳脚跟， 他们便向西推进， 直到殖民时期结束时，他们已经登上了阿勒格尼山脉的山顶。

And by the close of the 20th century, Las Vegas had earned the distinction of being the most populous city in North America that was founded within the same century, just like Chicago had been during the 19th century.

到 20 世纪末，拉斯维加斯已经顺利成为北美人口最多的城市，这是在同一世纪内建立的城市，就像芝加哥在 19 世纪的发展一样。