蟾毒色胺是一种与血清素相关的色胺类物质，是存在于某些蟾蜍皮肤（得名于蟾蜍属）、蘑菇、高等植物和哺乳动物中的生物碱，结构与二甲基色胺、脱磷酸裸盖菇素和5-甲氧基二甲基色胺类似。最早由奥地利化学家汉多夫斯基（Handovsky）在一战期间从蟾蜍皮肤中提取得到。1934年维兰德证实其结构，1936年星野敏雄完成合成。

Bufotenin (5-HO-DMT, N,N-dimethylserotonin, bufotenine) is a tryptamine related to the neurotransmitter serotonin. It is an alkaloid found in the skin of some species of toads; in mushrooms, higher plants, and mammals.

The name bufotenin originates from the Bufo genus of toads, which includes several species of psychoactive toads, most notably Incilius alvarius, that secrete bufotoxins from their parotoid glands. Bufotenin is similar in chemical structure to the psychedelics psilocin (4-HO-DMT), 5-MeO-DMT, and DMT, chemicals which also occur in some of the same fungus, plant, and animal species as bufotenin. The psychoactivity of bufotenin has been disputed, though recent studies suggest it is similar in nature to 5-MeO-DMT.