Zotob是一个电脑蠕虫，感染对象主要是微软的Windows XP以及Windows 2000操作系统。该病毒利用了微软公司于2005年8月9日公布的编号为MS05－039的随插即用中的漏洞。从漏洞的发布到病毒的出现仅用了七天左右的时间。病毒的破坏有：造成系统频繁重启，为系统留后门，阻止安装在系统中的反病毒软件升级。这只电脑蠕虫现时已经出现多个变种，并使部份地区的网上通信开始瘫痪。

Zotob有多个别名，当中包括Rbot（cbq、ebq等）。它利用微软网络（microsoft-ds）上的TCP端口445散布。

"The Zotob worm and several variations of it, known as Rbot.cbq, SDBot.bzh and Zotob.d, infected computers at companies such as ABC, CNN, The Associated Press, The New York Times, and Caterpillar Inc." — Business Week, August 16, 2005.

Zotob is a computer worm which exploits security vulnerabilities in Microsoft operating systems like Windows 2000, including the MS05-039 plug-and-play vulnerability. This worm has been known to spread on Microsoft-ds or TCP port 445.

It was declared that the Zotob worms cost an average of $97,000 as well as 80 hours of cleanup per company affected.