Zona glomerulosa

The zona glomerulosa of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the renal capsule. Its cells are ovoid and arranged in clusters or arches (glomus is Latin for "ball").

In response to increased potassium levels, renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system. Although sustained production of aldosterone requires persistent calcium entry through low-voltage activated Ca channels, isolated zona glomerulosa cells are considered nonexcitable, with recorded membrane voltages that are too hyperpolarized to permit Ca channels entry. However, mouse zona glomerulosa cells within adrenal slices spontaneously generate membrane potential oscillations of low periodicity; this innate electrical excitability of zona glomerulosa cells provides a platform for the production of a recurrent Ca channels signal that can be controlled by angiotensin II and extracellular potassium, the 2 major regulators of aldosterone production. Aldosterone regulates the body's concentration of electrolytes, primarily sodium and potassium, by acting on the distal convoluted tubule of kidney nephrons to: increase sodium reabsorption, increase potassium excretion, increase water reabsorption through osmosis.

单词	Zona glomerulosa
释义	Zona glomerulosa 原声例句 Osmosis-内分泌 The adrenal cortex is the outer part of the adrenal gland and is subdivided into three layers- the zona glomerulosa, the zona fasciculata, and the zona reticularis. 肾上腺皮质是肾上腺的外层部分，皮质又分为三层：球状带、束状带和网状带。 Osmosis-内分泌 Second, cortisol starts cross-reacting with mineralocorticoid receptors, which normally only binds a related steroid hormone - mineralocorticoids which are secreted from the zona glomerulosa layer of the adrenal cortex. 第二，皮质醇对盐皮质激素受体产生交叉反应；此类受体一般只与一种相关的类固醇激素结合，即从肾上腺皮质的球状带层分泌的盐皮质激素。 Osmosis-内分泌 The most common primary cause is called idiopathic hyperaldosteronism, because the zona glomerulosa has an increase in the number of cells secreting aldosterone, but it's not really clear why this happens. 最常见的原发性病因称为特发性醛固酮增多症：这是由于球状带分泌醛固酮的细胞数量增加，但目前尚不清楚为什么会发生这种情况。 Osmosis-内分泌 In primary hyperaldosteronism, the main problem is that zona glomerulosa cells secrete high levels of aldosterone, and that aldosterone has a negative feedback effect on renin, and so it actually inhibits renin production. 在原发性醛固酮增多症中，主要问题是球状带细胞分泌高水平的醛固酮；醛固酮对肾素有负反馈作用，因而实际上抑制肾素生成。 Osmosis-内分泌 All right, as a quick recap, hyperaldosteronism is the chronic, excess secretion of aldosterone from the zona glomerulosa of the adrenal gland, and these high aldosterone levels can lead to hypokalemia, hypernatremia, hypertension, and a metabolic alkalosis. 得！简单回顾一下：醛固酮增多症是指肾上腺球状带长期分泌过多的醛固酮；这些高醛固酮水平可导致低钾血症、高钠血症、高血压与代谢性碱中毒。英语百科 Zona glomerulosa The zona glomerulosa of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the renal capsule. Its cells are ovoid and arranged in clusters or arches (glomus is Latin for "ball"). In response to increased potassium levels, renin or decreased blood flow to the kidneys, cells of the zona glomerulosa produce and secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system. Although sustained production of aldosterone requires persistent calcium entry through low-voltage activated Ca channels, isolated zona glomerulosa cells are considered nonexcitable, with recorded membrane voltages that are too hyperpolarized to permit Ca channels entry. However, mouse zona glomerulosa cells within adrenal slices spontaneously generate membrane potential oscillations of low periodicity; this innate electrical excitability of zona glomerulosa cells provides a platform for the production of a recurrent Ca channels signal that can be controlled by angiotensin II and extracellular potassium, the 2 major regulators of aldosterone production. Aldosterone regulates the body's concentration of electrolytes, primarily sodium and potassium, by acting on the distal convoluted tubule of kidney nephrons to: increase sodium reabsorption, increase potassium excretion, increase water reabsorption through osmosis.
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