Zarza de Granadilla is a Spanish municipality in Cáceres Province, Extremadura. Zarza de granadilla has a population of 1873.

Is situated at the north of the province of caceres, between the valley of the river Ambroz and Alagon. It limits with sotoserrano, the Gabriel y Galan reservoir, villar de plasencia, jarilla, casas del monte, lagunilla, abadia and granja de granadilla. It has a total area of 134 km2.