薛姓是一个东亚文化圈的姓氏，在古籍《百家姓》中排名第68位。值得注意的是「薛」与「薜」的写法相当接近。

「薛」主要源出有三：

Xue ([ɕy̯é]) is the pinyin romanization of the Chinese surname 薛 (Xuē). It is romanized as Hsüeh in Wade-Giles. In Hong Kong and Macau it is usually romanized through its Cantonese pronunciation Sit. In Korean, it corresponds to Seol (설), in Japanese to Setsu and in Vietnamese to Tiết. According to the 2010 Chinese Census, it is the 76th most common surname in China, a sharp decline from 48th in 1982. In a study by geneticist Yuan Yida on the distribution of Chinese surnames, people who carry the name Xue are dispersed throughout the country and is most heavily concentrated in Shaanxi.