伍斯特理工学院（英语：Worcester Polytechnic Institute，缩写WPI），旧译：吴士脱大学，是一所位于美国马萨诸塞州伍斯特市的私立大学。

伍斯特理工学院（WPI）于1865年建校，是全美国最早的理工大学之一,历史悠久。WPI是是一所小型的私立大学，学校以小班授课为主，伍斯特理工学院拥有14个院系，提供超过50种学位项目，包括理科、工程类学科、商科、社科及人文学科，学生可获学士，硕士，及哲学博士学位。伍斯特理工学院的教职人员与学生共同在很多研究领域工作，这些领域包括生物科技，能源，信息安全，纳米科技以及材料处理。该校比较好的专业有机械工程，电子工程和计算机工程等。

Worcester Polytechnic Institute (WPI) is a private research university in Worcester, Massachusetts, focusing on the instruction and research of technical arts and applied sciences.

Founded in 1865 in Worcester, WPI was one of the United States' first engineering and technology universities and now has 14 academic departments with over 50 undergraduate and graduate degree programs in science, engineering, technology, management, the social sciences, and the humanities and arts, leading to bachelor's, master's and PhD degrees. WPI's faculty works with students in a number of research areas, including biotechnology, fuel cells, information security, materials processing, and nanotechnology.