螺丝（英语：screw）即螺（丝）钉，是一种常见的紧固件，在机械、电器及建筑物上广泛使用。一般材质为金属或塑胶，呈圆柱形，表面刻有凹凸的沟称为螺纹。螺纹是一个环绕螺丝侧面的螺旋倾斜面，让螺丝可应用螺旋机制紧锁着螺丝帽或其他物体，这些物体的内侧有和螺丝相对应的螺纹，称为内螺纹。一般螺丝帽或其他对象的内螺丝需另外加工产生，不过有一种螺丝称为自攻螺丝，可以在较软的物体上切削出内螺纹，因此不需特别的加工。

螺丝的主要功用是接合二个物体，或者是固定一物体的位置。螺丝通常可随意移除或重新嵌紧而不损其效率，亦比钉提供更大的力量，也可重复使用。

A screw is a type of fastener, sometimes similar to a bolt (see Differentiation between bolt and screw below), typically made of metal, and characterized by a helical ridge, known as a male thread (external thread) or just thread. A screw is an inclined plane wrapped around a nail. Some screw threads are designed to mate with a complementary thread, known as a female thread (internal thread), often in the form of a nut or an object that has the internal thread formed into it. Other screw threads are designed to cut a helical groove in a softer material as the screw is inserted. The most common uses of screws are to hold objects together and to position objects.