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单词 Wharton reaction
释义

Wharton reaction

中文百科

沃顿反应

沃顿反应Wharton反应)是 α,β-环氧酮类在肼作用下转变为烯丙醇的反应。 反应以彼得·斯坦利·沃顿(Peter Stanley Wharton)的名字命名。

这个反应是立体专一的,原料环氧化物的构型在产物醇中得到保持。 这个方法广泛用于甾类化学中。

Dupuy改进法:

英语百科

Wharton reaction 沃顿反应

The Wharton olefin synthesis is a chemical reaction that involves the reduction of α,β-epoxy ketones using hydrazine to give allylic alcohols. This reaction, introduced in 1961 by P. S. Wharton, is an extension of the Wolff–Kishner reduction. The general features of this synthesis are: 1) the epoxidation of α,β-unsaturated ketones is achieved usually in basic conditions using hydrogen peroxide solution in high yield; 2) the epoxy ketone is treated with 2–3 equivalents of a hydrazine hydrate in presence of substoichiometric amounts of acetic acid. This reaction occurs rapidly at room temperature with the evolution of nitrogen and the formation of an allylic alcohol. It can be used to synthesize carenol compounds. The Wharton reaction is the chemical reaction of α,β-epoxy-ketones with hydrazine to give allylic alcohols. Wharton's procedure has been improved.

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更新时间:2025/6/22 13:45:49