Villarrubia de los Ojos is a municipality in Ciudad Real, Castile-La Mancha, Spain. According to the 2010 census the municipality has a population of 11,119 inhabitants.

The Ojos del Guadiana are located within the Villarrubia de los Ojos municipal term. They are the source of the Guadiana river, the fourth longest river of the Iberian peninsula. There's also a National Park, the Tablas de Daimiel National Park located in the Tablas de Daimiel wetlands, shared with the neighbouring municipality, Daimiel.