Vesicular monoamine transporter

A Hydrogen atom from the inside of the vesicle binds, inducing a conformational change in the transporter

The conformational change induced by the hydrogen atom binding enables the monoamine binding to the active transport site

A second hydrogen atom binds from inside the vesicle to the transporter inducing another change

The monoamine is released inside the vesicle and the two hydrogen atoms are released into the cytosol and the transport process starts over again.

The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membrane of synaptic vesicles of presynaptic neurons. It acts to transport monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters into synapses as chemical messages to postsynaptic neurons. VMATs utilize a proton gradient generated by V-ATPases in vesicle membranes to power monoamine import.

单词	Vesicular Monoamine Transporter
释义	Vesicular Monoamine Transporter 英语百科 Vesicular monoamine transporter The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membrane of synaptic vesicles of presynaptic neurons. It acts to transport monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters into synapses as chemical messages to postsynaptic neurons. VMATs utilize a proton gradient generated by V-ATPases in vesicle membranes to power monoamine import.
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Vesicular Monoamine Transporter

Vesicular monoamine transporter