硼替佐米（INN名称：Bortezomib，原代号名PS-341），千禧制药定商品名为Velcade，**的正式商品名为万科，中国大陆的正式商品名为万珂，硼替佐米是其主成分，是一种癌症治疗药物，是全球第一个合成的蛋白酶体抑制剂（proteasome inhibitor），可延缓、停止及治疗多发性骨髓瘤和被套细胞淋巴瘤恶化的情况，属于标靶治疗的新型抗癌药。对蛋白酶体的抑制作用是可逆的，所以有可控管的及可预测的用药安全性为其最大优势。

Bortezomib (BAN, INN and USAN. Originally codenamed PS-341; marketed as Velcade by Millennium Pharmaceuticals; Neomib by Getwell and Bortecad by Cadila Healthcare) is the first therapeutic proteasome inhibitor to be tested in humans. Proteasomes are cellular complexes that break down proteins. In some cancers, the proteins that normally kill cancer cells are broken down too quickly. Bortezomib interrupts this process and lets those proteins kill the cancer cells. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.