血管内皮生长因子（英文：vascular endothelial growth factor，简称：VEGF），早期亦称作血管通透因子（英文：vascular permeability factor，简称：VPF)，是对血管内皮细胞具有特异性的肝素结合生长因子（heparin-binding growth factor），可在体内诱导血管新生（induce angiogenesis in vivo）。

人的VEGF蛋白是于****年由美国的两间生物科技公司分别成功纯化与鉴定，并克隆与测定了其基因串行，证明VPF与VEGF是同一基因编码的同一蛋白。VEGF有六个等型（isoforms）：VEGF-A, -B（包括VEGF-B167以及VEGF-B186）, -C, -D, 及-E；其分子量从35至44kDa不等，每个等型特异性地与三个「血管内皮生长因子受体」（VEGFR-1, -2, 及-3)的特定组合相结合。其中每种因子作用各不相同，但都与促进血管及淋巴管等人体脉管的生成与分化相关。

Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate such as in hypoxic conditions. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.