美国海关及边境保卫局（英文：U.S. Customs and Border Protection，缩写：CBP）是美国国土安全部规范和促进国际贸易，征收进口关税，并且运行美国贸易法律的一个机构。其主要任务是防止恐怖分子和恐怖武器进入美国。海关及边境保卫局亦负责逮捕企图非法进入美国的个人、非法毒品和其他违禁品，保护美国的农业和经济利益不受有害的害虫和疾病，并保护美国的企业不被窃取知识产权。

U.S. Customs and Border Protection (CBP) is the largest federal law enforcement agency of the United States Department of Homeland Security. It is charged with regulating and facilitating international trade, collecting import duties, and enforcing U.S. regulations, including trade, customs, and immigration. CBP is the largest law enforcement agency in the United States. It has a workforce of more than 45,600 sworn federal agents and officers. It has its headquarters in Washington, D.C.