美国国际开发署（英语：United States Agency for International Development，缩写：USAID），是承担美国大部分对外非军事援助的联邦政府机构，继承国际合作总署（International Cooperation Administration）的职能。美国国际开发署作为一个独立的联邦机构，依照美国国务院的外交政策，力求“为海外那些为过上美好生活而努力、进行着灾后重建、以及为求生活于民主自由之国家而奋斗的人们提供帮助”。

The United States Agency for International Development (USAID) is the United States Government agency which is primarily responsible for administering civilian foreign aid.

President John F. Kennedy created USAID from its predecessor agencies in 1961 by Executive Order. USAID's programs are authorized by the Congress in the Foreign Assistance Act, which the Congress supplements through directions in annual funding appropriation acts and other legislation. Although it is technically an independent agency, USAID operates subject to the foreign policy guidance of the President, Secretary of State, and the National Security Council. USAID operates in Africa, Asia, Latin America, the Middle East, and Eastern Europe.