"Uaupes" redirects here. For the river, see Vaupés River.

São Gabriel da Cachoeira (Saint Gabriel of the Waterfall) is a municipality located on the northern shore of the Rio Negro River, in the region of Cabeça do Cachorro, Amazonas state, Brazil. Between 1952 and 1966, it was officially called Uaupés, after the nearby Vaupés River. Most of its inhabitants are indigenous people. The city's population is somewhere around 13,000, but the entire region has 40,806 people (2008), scattered over 109,185 km, mostly indigenous peoples in surrounding tribes and villages.