Transverse relaxation-optimized spectroscopy
(重定向自TROSY)
Transverse relaxation optimized spectroscopy (TROSY) is an experiment in protein NMR spectroscopy that allows studies of large molecules or complexes.
The application of NMR to large molecules is normally limited by the fact that the line widths generally increase with molecular mass. Larger molecules have longer rotational correlation times and consequently shorter transverse relaxation times (T2). In other words, the NMR signal from larger molecules decays more rapidly, leading to line broadening in the NMR spectrum and poor resolution.