Tripamide
![Tripamide synthesis:[1]](/uploads/202502/17/Tripamide_synthesis.svg1338.png)
Tripamide (INN) is a diuretic.
Preparation starts by exhaustive reduction of the Diels-Alder adduct from cyclopentadiene and maleimide (1). Nitrosation of the product (2), followed by reduction of the nitroso group of 3, gives the corresponding hydrazine (4). Acylation with acid chloride 5 gives tripamide (6).