三环类抗抑郁药（英语：Tricyclic antidepressants (TCAs)）是一类以化学结构命名的抗抑郁药，主要用来治疗抑郁症。阿米替林是现今使用最广泛的TCA类药物。

Tricyclic antidepressants are chemical compounds used primarily as antidepressants. TCAs were first discovered in the early 1950s and marketed later in the decade. They are named after their chemical structure, which contains three rings of atoms. Tetracyclic antidepressants (TeCAs), which contain four rings of atoms, are a closely related group of antidepressant compounds.