Toxication

（重定向自Toxification）

Enzyme CYP3A4, in CYP3A subfamily, contributes to hepatotoxicity during metabolism

Toxication or toxification is the conversion of a chemical compound into a more toxic form in living organisms or in substrates such as soil or water. The conversion can be caused by enzymatic metabolism in the organisms, as well as by abiotic chemical reactions. While the parent drug are usually less active, both the parent drug and its metabolite can be chemically active and cause toxicity, leading to mutagenesis, teratogenesis, and carcinogenesis. Different classes of enzymes, such as P450-monooxygenases, epoxide hydrolase, or acetyltransferases can catalyze the process in the cell, mostly in the liver.

单词	Toxification
释义	Toxification 英语百科 Toxication （重定向自Toxification） Toxication or toxification is the conversion of a chemical compound into a more toxic form in living organisms or in substrates such as soil or water. The conversion can be caused by enzymatic metabolism in the organisms, as well as by abiotic chemical reactions. While the parent drug are usually less active, both the parent drug and its metabolite can be chemically active and cause toxicity, leading to mutagenesis, teratogenesis, and carcinogenesis. Different classes of enzymes, such as P450-monooxygenases, epoxide hydrolase, or acetyltransferases can catalyze the process in the cell, mostly in the liver.
随便看	whoat的意思 Who Ate All the Pies的意思 whoave的意思 whobble的意思 who but的意思 who can...的意思 Who Can Say的意思 Who Can Say的意思 who can tell的意思 who care的意思 Who Cares的意思 Who Cares的意思 whoch的意思 whoche的意思 whochesafe的意思 WHO Chronicle的意思 WHO Collaborating Centre for Chemical Reference Substances的意思 who command的意思 who could have的意思 WHOD的意思 whoder的意思 whodi的意思 who died and made you boss的意思 Whodini的意思 whodis的意思