Porphyria

Heme synthesis—note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)

Maria I of Portugal in a c. 1790s portrait attributed to Giuseppe Troni or Thomas Hickey.

The porphyrias( poor-FEAR-e-uh) are a group of rare diseases in which chemical substances called porphyrins accumulate with high metabolism. The body requires porphyrins to produce heme, which carries oxygen in the blood. But in the porphyrias, there is a deficiency (inherited or acquired) of the enzymes that transform the various porphyrins into others, leading to abnormally high levels of one or more of these substances. This manifests with neurological symptoms or skin problems, or occasionally both.

单词	Toxic porphyria
释义	Toxic porphyria 英语百科 Porphyria The porphyrias( poor-FEAR-e-uh) are a group of rare diseases in which chemical substances called porphyrins accumulate with high metabolism. The body requires porphyrins to produce heme, which carries oxygen in the blood. But in the porphyrias, there is a deficiency (inherited or acquired) of the enzymes that transform the various porphyrins into others, leading to abnormally high levels of one or more of these substances. This manifests with neurological symptoms or skin problems, or occasionally both.
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Toxic porphyria

Porphyria