托普乐肯（Topotecan；商品名：Hycamtin®，癌康定）是一种化学治疗药物，为拓朴异构酶I抑制物，一般用来治疗卵巢癌与肺癌等癌症。

为静脉注射，不过有口服的研究。

Topotecan (trade name Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.