In addition to that Tolcapone has been associated with liver toxicity.

除此之外，托卡彭还与肝脏毒性有关。

So, here another useful drugs come into play, namely Selegiline and Rasagiline, which selectively inhibit MAO-B, and Tolcapone, which inhibits COMT.

因此，另一种有用的药物开始发挥作用，即塞来吉林和拉沙吉林，它们选择性地抑制MAO-B和Tolcapone，后者抑制COMT。

Entacapone and Tolcapone may cause discoloration of urine, sweat or saliva, and diarrhea, which can get severe particularly with the use of Tolcapone.

恩他卡彭和托卡彭可能导致尿液、汗液或唾液变色，以及腹泻尤其是使用托卡彭后会变得更严重。

COMT inhibitors like entacapone and tolcapone are only given with levodopa to prevent the enzyme from breaking it down outside the central nervous system, thus allowing more of it to enter the brain.

COMT抑制剂，例如恩他卡朋和托卡朋与左旋多巴一起用于治疗，只是为了防止左旋多巴在中枢神经系统外被分解，从而使更多左旋多巴进入脑中。

As a side note here, in comparison to Entacapone, Tolcapone can better penetrate the blood–brain barrier, and thus can act both in the central nervous system and in the periphery.

另一方面，与恩他卡彭相比，托卡彭能更好地穿透血液-大脑屏障，因此可以在中枢神经系统和周围发挥作用。