虎狮兽（Tigon）是雄虎跟雌狮的人工圈养混种后代，是比狮虎兽更罕见的混种。

因栖境跟行为的不同，虎狮兽不会自然产生。就如狮虎兽，虎狮兽也有其父母的混合特征，如兼有狮子的斑点和老虎的条纹，吼叫声兼有亲种的特征，雄虎狮会有较狮子小的鬃毛。但与狮虎兽不同的是，老虎控制体型生长的基因是由公虎遗传的，狮子控制体型生长的基因却是由母狮遗传，所以公虎母狮交配生下的虎狮只能长到与其父母相当的体型，而不会像狮虎兽般体型比狮或虎都要硕大。

在生育力方面，普遍认为大部分的狮虎混种为不育，雄性虎狮皆不育，但雌性虎狮兽比狮虎兽有较高的机率具有繁殖力。

A tigon /ˈtaɪɡən/ or tiglon /ˈtaɪɡlən/ is a hybrid cross between a male tiger (Panthera tigris) and a female lion (Panthera leo). Thus, it has parents with the same genus but of different species. The tigon is not currently as common as the converse hybrid, the liger; however, in the late 19th and early 20th centuries, Gerald Iles wrote that he had been able to obtain three tigons, but he had never seen a liger.