Thymidylate synthase

（重定向自Thymidylate synthetase）

This shows the overall pathway that thymidylate synthase and it's intermediates take

Thymidylate synthetase (EC2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUTP arise. Both cause DNA damage.

单词	Thymidylate synthetase
释义	Thymidylate synthetase 英语百科 Thymidylate synthase （重定向自Thymidylate synthetase） Thymidylate synthetase (EC2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUTP arise. Both cause DNA damage.
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