Not to be confused with Berger's disease (IgA nephropathy)

Thromboangiitis obliterans (also known as Buerger's disease, Buerger disease [English /bʌrɡər/; German /byrgər/], or presenile gangrene ) is a recurring progressive inflammation and thrombosis (clotting) of small and medium arteries and veins of the hands and feet. It is strongly associated with use of tobacco products, primarily from smoking, but is also associated with smokeless tobacco.