Thioflavin

Thioflavin S stain (left in green) and amyloid-Beta antibody immunocytochemistry (right) on adjacent sections of the hippocampus of a patient suffering from Alzheimer's disease. Thioflavin S binds both senile plaques (SP) and neurofibrillary tangles (NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the amyloid precursor protein which is only found in senile plaques, and so only plaques are visible in the right hand image. The left image also has a red signal which exactly superimposes the green signal in lipofuscin granules (LP), which are autofluorescent inclusions derived from lysosomes which accumulate in the human brain during normal aging.

Thioflavins are dyes used for histology staining and biophysical studies of protein aggregation. They are also used in biophysical studies of the electrophysiology of bacteria.

单词	Thioflavin
释义	Thioflavin 英语百科 Thioflavin Thioflavins are dyes used for histology staining and biophysical studies of protein aggregation. They are also used in biophysical studies of the electrophysiology of bacteria.
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