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单词 tetrahydrobiopterin
释义

tetrahydrobiopterin /ˌtetrə,haidrə'baiəupterin/

英汉-汉英词典
n. 四氢生物蝶呤
词组 | 习惯用语
tetrahydrobiopterin n. 四氢生物蝶呤

网络短语:
tetrahydrobiopterin bh 四氢生物蝶呤
tetrahydrobiopterin responsive 四氢生物蝶呤反应性
tetrahydrobiopterin loading test 四氢生物蝶呤负荷试验
原声例句
经济学人 Science and technology

After testing the impact of these drugs on mouse neurons, they identified one candidate—fluphenazine, previously prescribed for schizophrenia—that successfully inhibited not only tetrahydrobiopterin but pain too.

在测试了这些药物对小鼠神经元的影响后,他们确定了一种候选药物——氟奋乃静,以前曾为精神分裂症开过处方——它不仅成功地抑制了生物蝶呤,而且还成功地抑制了疼痛。

经济学人 Science and technology

Though the precise connection between tetrahydrobiopterin and pain is still unclear, Dr Cronin and colleagues are nonetheless looking for ways to reduce its levels in the body.

尽管四氢生物蝶呤与疼痛之间的确切联系仍不清楚,但 Cronin 博士及其同事仍在寻找降低其在体内水平的方法。

经济学人 Science and technology

Shane Cronin, a biologist at Harvard Medical School, is part of a team of researchers that has spent more than a decade identifying a correlation between chronic pain and levels of a naturally occurring molecule in the body known as tetrahydrobiopterin.

哈佛医学院的生物学家 Shane Cronin 是一个研究小组的成员,该小组花了十多年时间确定慢性疼痛与体内天然存在的生物蝶呤分子水平之间的相关性。

中文百科

四氢生物蝶呤

Schema des Redoxsystems 5,6,7,8-Tetrahydrobiopterin (1), 4a-Hydroxytetrahydrobiopterin (2) und 6,7-Dihydrobiopterin (3). Eine Tetrahydrobiopterin-abhängige Monooxygenase (A) hydrolysiert einen Aromaten, wodurch 4a-Hydroxytetrahydrobiopterin entsteht. Dieses wird zu 6,7-Dihydrobiopterin unter Abspaltung von Wasser umgesetzt, was eine 4a-Hydroxytetrahydrobiopterin-Dehydratase (B) katalysiert. Die 6,7-Dihydropteridin-Reduktase (C) schließlich ermöglicht die NAD(P)H-abhängige Umwandlung von 5,6,7,8-Tetrahydrobiopterin und 6,7-Dihydrobiopterin.

四氢生物蝶呤tetrahydrobiopterin),又称沙丙蝶呤Sapropterin),简称BH4, 是三种芳香族氨基酸羟化酶的一种重要辅酶:苯丙氨酸羟化酶将苯丙氨酸转化为酪氨酸;酪氨酸羟化酶将酪氨酸转化为左旋多巴;色氨酸羟化酶将色氨酸转化为5-羟色胺酸。它也是一氧化氮合酶(NOS)合成NO的重要辅酶。

英语百科

Tetrahydrobiopterin 四氢生物蝶呤

Schema des Redoxsystems 5,6,7,8-Tetrahydrobiopterin (1), 4a-Hydroxytetrahydrobiopterin (2) und 6,7-Dihydrobiopterin (3). Eine Tetrahydrobiopterin-abhängige Monooxygenase (A) hydrolysiert einen Aromaten, wodurch 4a-Hydroxytetrahydrobiopterin entsteht. Dieses wird zu 6,7-Dihydrobiopterin unter Abspaltung von Wasser umgesetzt, was eine 4a-Hydroxytetrahydrobiopterin-Dehydratase (B) katalysiert. Die 6,7-Dihydropteridin-Reduktase (C) schließlich ermöglicht die NAD(P)H-abhängige Umwandlung von 5,6,7,8-Tetrahydrobiopterin und 6,7-Dihydrobiopterin.

Tetrahydrobiopterin (BH4, THB, trade name Kuvan) or sapropterin (INN) is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.

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更新时间:2025/6/20 14:52:51