SV40 large T antigen

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function.

单词	T antigen
释义	T antigen 英语百科 SV40 large T antigen SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function.
随便看	radiopaque dye的意思 radiopaque dyes的意思 radiopaque gallstone的意思 radiopaque marker的意思 radiopaque marking的意思 radiopaque material的意思 radiopaque materials的意思 radiopaque measuring scale的意思 Radiopaque Media的意思 radiopaque medium的意思 radiopaque polyethylene tube的意思 radiopaque polyfluoroethylene tube的意思 radiopaque polyurethane tube的意思 radiopaque polyvinyl chloride的意思 radiopaque的意思 radiopaque sponge的意思 radiopaque structure的意思 radio parameter measuring instrument的意思 radio parameters measurement的意思 radioparency的意思 radioparent的意思 radioparent calculus的意思 radioparent sternalade的意思 radioparent sternal blade的意思 radio part的意思