So in 1863 an American named John Wesley Hyatt took up the challenge.

因此，在 1863 年，一位名叫约翰·韦斯利·凯悦的美国人接受了挑战。

Rick took up the challenge and cycled the 250-mile route alone.

【take】里克接受挑战，独自骑自行车骑行了 250 英里。

Thus, when Hofmann made some passing comments about the desirability of a synthetic substitute for quinine, it was unsurprising that his star pupil was moved to take up the challenge.

因此， 当霍夫曼对奎宁的合成替代品的可取性发表了一些顺便的评论时，他的明星学生被感动接受挑战也就不足为奇了。

One lawyer who can be said to have taken up the challenge was John Eastman, a senior fellow at the institute for 30 years and the founder and director of Claremont's Center for Constitutional Jurisprudence.

可以说有一位律师接受了这一挑战，他就是约翰·伊斯特曼，他在该研究所担任了 30 年的高级研究员，也是克莱蒙特宪法法学中心的创始人和主任。