Ankylosing spondylitis is a systemic inflammatory disease, so it can cause symptoms, like weight loss, fevers, and fatigue.

强直性脊柱炎是一种全身性的炎症性疾病，因此能够引起全身症状，如体重减轻、发热和疲劳。

They can also increase the risk of developing systemic diseases such as cardiovascular disease, pneumonia, pancreatic cancer or colorectal cancer.

这些改变还会增加罹患心血管疾病、肺炎、胰腺癌或结直肠癌等系统性疾病的风险！

Although diabetes and hypertension are responsible for the vast majority of CKD cases, there are other systemic diseases like lupus and rheumatoid arthritis, can also cause glomerulosclerosis.

尽管糖尿病和高血压是慢性肾病的主要病因，也有其他疾病如狼疮、类风湿性关节炎能导致肾小球硬化。

Also, some systemic diseases such as diabetes, rheumatoid arthritis, and systemic lupus erythematosis can enhance inflammation in the periodontium which can lead to a shift in bacterial composition and increase the risk or severity of periodontitis.

此外，某些系统性疾病，例如糖尿病、类风湿关节炎、系统性红斑狼疮，会增加牙周组织炎症，从而改变口腔微生物群中细菌的组成，并增大患牙周炎的风险或加重牙周炎。