超分子化学（英语：Supramolecular chemistry）是化学的一门分支，专注于分子之间的非共价键结作用。相较于传统化学上所研究的共价键，超分子化学的研究对象是一些较弱且较具可恢复性的分子间作用，例如氢键、金属配位、π-π堆积、厌水性效应、范德华力以及重叠作用等。而超分子化学从这些研究中阐明了一些新概念，例如分子的自组装、折叠、分子识别（molecular recognition）、主-客体化学（host-guest chemistry）等。在生物学领域中，借助了许多超分子化学领域研究方法及成果来了解生物系统的运作。

Supramolecular chemistry refers to the domain of chemistry beyond that of molecules and focuses on the chemical systems made up of a discrete number of assembled molecular subunits or components. The forces responsible for the spatial organization may vary from weak (intermolecular forces, electrostatic or hydrogen bonding) to strong (covalent bonding), provided that the degree of electronic coupling between the molecular component remains small with respect to relevant energy parameters of the component. While traditional chemistry focuses on the covalent bond, supramolecular chemistry examines the weaker and reversible noncovalent interactions between molecules. These forces include hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic effects. Important concepts that have been demonstrated by supramolecular chemistry include molecular self-assembly, folding, molecular recognition, host-guest chemistry, mechanically-interlocked molecular architectures, and dynamic covalent chemistry. The study of non-covalent interactions is crucial to understanding many biological processes from cell structure to vision that rely on these forces for structure and function. Biological systems are often the inspiration for supramolecular research.