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单词 sulfinalol
释义

sulfinalol

英汉-汉英词典
磺苄心定
词组 | 习惯用语
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  • finalist n. 参加决赛的选手
  • sulfonamide n. 硫安类药剂
英语百科

Sulfinalol

Sulfinalol synthesis: R. E. Philion, DE 2728641  (1978 to Sterling), C.A. 90, 137468 (1979).

Sulfinalol is a beta adrenergic receptor antagonist.

The methyl group on a sulfoxide interestingly proves sufficiently acidic to substitute for phenolic hydroxyl.

The preparation of this combined α- and β-blocker sulfinalol begins by protection of the phenolic hydroxyl as its benzoate ester. Bromination followed by condensation with 4-(4-methoxyphenyl)butan-2-amine (not PMA) gives the aminoketone 3. Successive catalytic reduction and saponification affords aminoalcohol 4. Oxidation of the sulfide to the sulfoxide with a reaagent such as metaperiodate gives sulfinalol (5).

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更新时间:2025/6/23 13:56:14