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单词 ACO1
释义

ACO1

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In this paper, ACO algorithm is reviewed by and large.Firstly, the corresponding principle of biont and the implementing framework for ACO algorithm are introduced simply.

摘要本文首先简要地介绍蚁群优化算法的来源、对应的生物原理和算法实现的框架。

英语百科

ACO1

Aconitase 1, soluble is a protein that in humans is encoded by the ACO1 gene.

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

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更新时间:2025/6/22 3:20:26