It may result in substantial changes: you might move paragraphs around and rewrite them to make them fit elsewhere.

它可能会导致实质性的变动：你可能会移动段落，重写段落，使其与其他内容相称。

But its leadership has endured the substantial changes.

但其领导层经历了重大变化。

There are other pilot projects like this in different countries, but for them to scale, our policy frameworks and electricity market design need to undergo substantial changes.

各国都有这样的试点项目，但如果要扩大规模，我们的政策框架和电力市场设计必须发生巨变。

It is only in a highly authoritarian society, where sudden, substantial, all-round changes could be decreed that a flexible wage policy could function with success.

只有在高度专制的社会中， 突然的、实质性的、全面的变革才能下达， 灵活的工资政策才能成功发挥作用。

We expect that there will have to be some fairly substantial changes in our staffing patterns, as we need personnel to take up the tasks previously performed by others.

我们希望自己的人员配置模式也会有一些很大的变化，因为我们需要工作人员来承担此前由苏联公民承担的工作。

This practice pumps vast amounts of carbon dioxide into the atmosphere, and like our microbial predecessors, we have begun to make substantial changes to our planet.

这种做法将大量二氧化碳排放到大气中，就像我们的微生物祖先一样， 我们已经开始对我们的星球进行重大改变。