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单词 Substance addiction
释义

Substance addiction

原声例句
WIL生活启示录

Documented cases of internet addiction have shown the same dopamine receptor downregulation like you see in substance addiction.

有文件记录的网络成瘾案例显示,也有同样的多巴胺受体下降调节出现和你前面所见的物质成瘾一样。

WIL生活启示录

But how can simply using the internet cause changes in the brain similar to that of substance addiction?

但是,仅仅使用网络导致的大脑改变是怎样与物质成所导致的改变有相似性的呢?

Osmosis-精神心理

In alcohol or substance addiction, individuals tend to be more impulsive, taking risks they normally wouldn't take like driving recklessly.

在酒精或物质成瘾情况下,人变得更冲动,可能会冒险做一些他们在正常情况下不会做的事(如鲁莽开车)。

Osmosis-精神心理

There are a few mental health conditions that can increase the risk for suicide - in particular, clinical depression and alcohol or substance addiction.

有些精神健康疾病会增加自杀风险,尤其如临床抑郁症和酒精/物质成瘾。

读者文摘选编

I had worked with hundreds of people, from those wrestling with substance addiction and patterns of homelessness to private-practice clients facing decades-old abuse, trauma, and grief.

我曾帮助过成百上千个客户,从那些与药物成瘾和无家可归的模式作斗争的人,到那些面临着几十年的虐待、创伤和悲伤的私人诊所客户。

202323

If this translates to humans, lazier individuals may be less prone to substance addiction, although more research is needed to confirm this.

如果这适用于人类,那么懒惰的人可能不太容易上瘾,尽管需要更多的研究来证实这一点。

Asap SCIENCE 精选

Though it's a psychological addiction as opposed to a substance addiction, brain scans of these people actually show a similar impairment of regions that those with drug dependence have.

虽然这是心理成瘾而不是物质成瘾,但是扫描他们的大脑后发现,脑内损伤的区域和药物依赖者损伤的区域类似。

连线杂志

That particular brain region is active in all of the addictions, all the substance addictions, all the behavioral addictions like gambling, and it becomes just as active when you've been rejected in love.

这一特定的大脑区域在所有成瘾中都很活跃,所有物质成瘾,所有像赌博这样的行为成瘾,当你在爱情中被拒绝时会变得活跃。

AsapSCIENCE - Tech

Though it’s a psychological addiction as opposed to a substance addiction, brain scans of these people actually show a similar impairment of regions that those with drug dependence have.

虽然这是一种心理成瘾而不是物质成瘾,但对这些人的脑部扫描实际上显示出与药物依赖者相似的区域损伤。

PBS访谈健康系列

Drug abuse and substance addiction costs the United States nearly $600 billion dollars a year. They kill at least 320 Americans a day. And 90 percent of addicts start using drugs or alcohol before the age of 18.

药物滥用和药物成瘾每年给美国造成近 6000 亿美元的损失。他们每天至少杀死 320 名美国人。 90% 的瘾君子在 18 岁之前就开始吸毒或酗酒。

中文百科

成瘾 Addiction

(重定向自Substance addiction)
一个人在伊朗城市内沙布尔,可能吸毒。
El alcohol y el tabaco son las adicciones más comunes.


Signaling cascade in the nucleus accumbens that results in psychostimulant addiction

 
 

Note: colored text contains article links.

Nuclear pore
Nuclear membrane
Plasma membrane

Cav1.2
NMDAR
AMPAR
DRD1
DRD5
DRD2
DRD3
DRD4

Gs
Gi/o
cAMP
cAMP
PKA

CaM
CaMKII
DARPP-32
PP1
PP2B

CREB
ΔFosB
JunD
c-Fos
SIRT1
HDAC1

[Color legend 1]


This diagram depicts the signaling events in the brain's reward center that are induced by chronic high-dose exposure to psychostimulants that increase the concentration of synaptic dopamine, like amphetamine, methamphetamine, and phenethylamine. Following presynaptic dopamine and glutamate co-release by such psychostimulants,[35][36] postsynaptic receptors for these neurotransmitters trigger internal signaling events through a cAMP pathway and calcium-dependent pathway that ultimately result in increased CREB phosphorylation.[37][38][39]  Phosphorylated CREB increases levels of ΔFosB, which in turn represses the c-Fos gene with the help of corepressors;[38] c-Fos repression acts as a molecular switch that enables the accumulation of ΔFosB in the neuron.[40] A highly stable (phosphorylated) form of ΔFosB, one that persists in neurons for one or two months, slowly accumulates following repeated high-dose exposure to stimulants through this process.[41][42] ΔFosB functions as

成瘾英语:Addiction)是指一种重复性的强迫行为,即使这些行为已知可能造成不良后果的情形下,仍然被持续重复。这种行为可能因中枢神经系统功能失调造成,重复这些行为也可以反过来造成神经功能受损。

瘾被用于描述精神强迫或者过度的心理依赖,例如物质依赖,药物滥用(即俗称的滥药、毒瘾)、酒瘾、烟瘾、性瘾。或是持续出现特定行为(赌、暴食),网瘾、赌瘾、官瘾、财迷、工作狂、暴食症、色情狂、跟踪狂、偷窃狂、整形迷恋及购物狂等,是生理或者心理上,甚至是同时具备的一种依赖症。

英语百科

Addiction 成瘾

(重定向自Substance addiction)


Signaling cascade in the nucleus accumbens that results in psychostimulant addiction

 
 

Note: colored text contains article links.

Nuclear pore
Nuclear membrane
Plasma membrane

Cav1.2
NMDAR
AMPAR
DRD1
DRD5
DRD2
DRD3
DRD4

Gs
Gi/o
cAMP
cAMP
PKA

CaM
CaMKII
DARPP-32
PP1
PP2B

CREB
ΔFosB
JunD
c-Fos
SIRT1
HDAC1

[Color legend 1]


This diagram depicts the signaling events in the brain's reward center that are induced by chronic high-dose exposure to psychostimulants that increase the concentration of synaptic dopamine, like amphetamine, methamphetamine, and phenethylamine. Following presynaptic dopamine and glutamate co-release by such psychostimulants,[35][36] postsynaptic receptors for these neurotransmitters trigger internal signaling events through a cAMP pathway and calcium-dependent pathway that ultimately result in increased CREB phosphorylation.[37][38][39]  Phosphorylated CREB increases levels of ΔFosB, which in turn represses the c-Fos gene with the help of corepressors;[38] c-Fos repression acts as a molecular switch that enables the accumulation of ΔFosB in the neuron.[40] A highly stable (phosphorylated) form of ΔFosB, one that persists in neurons for one or two months, slowly accumulates following repeated high-dose exposure to stimulants through this process.[41][42] ΔFosB functions as
Top: this depicts the acute expression of various Fos family proteins following an initial exposure to an addictive drug.Bottom: this illustrates increasing ΔFosB expression from repeated twice daily drug binges, where these phosphorylated (35–37 kD) ΔFosB isoforms persist in mesolimbic dopamine neurons for up to 2 months.[52][42]

Addiction is a medical condition that is characterized by compulsive engagement in rewarding stimuli, despite adverse consequences. It can be thought of as a disease or biological process leading to such behaviors. The two properties that characterize all addictive stimuli are that they are reinforcing (i.e., they increase the likelihood that a person will seek repeated exposure to them) and intrinsically rewarding (i.e., something perceived as being positive or desirable).

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更新时间:2025/6/20 0:47:07