Strecker amino acid synthesis




The Strecker amino acid synthesis, also known simply as the Strecker synthesis, was devised by German chemist Adolph Strecker, and is a term used for a series of chemical reactions that synthesize an amino acid from an aldehyde or ketone. The aldehyde is condensed with ammonium chloride in the presence of potassium cyanide to form an α-aminonitrile, which is subsequently hydrolyzed to give the desired amino acid. In the original Strecker reaction acetaldehyde, ammonia, and hydrogen cyanide combined to form after hydrolysis alanine.