Stephen醛合成(Stephen aldehyde synthesis),由 Henry Stephen 发现并首先报道。
腈用氯化亚锡-盐酸处理,得相应的亚胺离子,然后再经水解,得醛。
英语百科
Stephen aldehyde synthesis Stephen醛合成
(重定向自Stephen reaction)
Stephen aldehyde synthesis, a named reaction in chemistry, was invented by Henry Stephen (OBE/MBE). This reaction involves the preparation of aldehydes (R-CHO) from nitriles (R-CN) using tin(II) chloride (SnCl2), hydrochloric acid (HCl) and quenching the resulting iminium salt ([R-CH=NH2]Cl) with water (H2O). During the synthesis, ammonium chloride is also produced.