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单词 Squalene synthase
释义

Squalene synthase

英语百科

Farnesyl-diphosphate farnesyltransferase

(重定向自Squalene synthase)
Squalene Synthase (Human). Key residues in the central channel are shown as spheres.

Squalene synthase (SQS) or farnesyl-diphosphate:farnesyl-diphosphate farnesyl transferase is an enzyme localized to the membrane of the endoplasmic reticulum. SQS participates in the isoprenoid biosynthetic pathway, catalyzing a two-step reaction in which two identical molecules of farnesyl pyrophosphate (FPP) are converted into squalene, with the consumption of NADPH. Catalysis by SQS is the first committed step in sterol synthesis, since the squalene produced is converted exclusively into various sterols, such as cholesterol, via a complex, multi-step pathway. SQS belongs to squalene/phytoene synthase family of proteins.

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更新时间:2025/6/21 5:19:16