Spybot – Search & Destroy (S&D) is a spyware and adware removal computer program compatible with Microsoft Windows 95 and later. It scans the computer hard disk and/or RAM for malicious software.

Spybot-S&D was written by the German software engineer Patrick Michael Kolla, and is distributed by Kolla's Irish company Safer-Networking Limited. Development began in 2000 when Kolla, still a student, wrote a small program to deal with the Aureate/Radiate and Conducent TimeSink programs, two of the earliest examples of adware.