In magnetic resonance, a spin echo is the refocusing of spin magnetisation by a pulse of resonant electromagnetic radiation. Modern nuclear magnetic resonance (NMR) and magnetic resonance imaging make use of this effect.

The NMR signal observed following an initial excitation pulse decays with time due to both spin relaxation and any inhomogeneous effects which cause different spins in the sample to precess at different rates. The first of these, relaxation, leads to an irreversible loss of magnetisation. However, the inhomogeneous dephasing can be removed by applying a 180° inversion pulse that inverts the magnetisation vectors. Examples of inhomogeneous effects include a magnetic field gradient and a distribution of chemical shifts. If the inversion pulse is applied after a period t of dephasing, the inhomogeneous evolution will rephase to form an echo at time 2t. In simple cases, the intensity of the echo relative to the initial signal is given by e where T₂ is the time constant for spin-spin relaxation.